This chapter introduces the concept of an advanced organizational concept to provide an integrated approach to project selection, portfolio management, and project management processes. The functions of an Enterprise Project Management Office (EPMO) organization were described and illustrated based on models that have surfaced from traditional Project Management Office (PMO). The organizational label PMO is most typically linked to information technology project selection within the enterprise; the basic principles are valid for the entire organizational level project portfolio. A physical organizational structure for EPMO has the same potential variability as that for a traditional PMO, meaning it can be focused on strategic planning, or fragmented and buried in various functional departments. The EPMO function must have an effective communication system between the project teams, key stakeholders, and senior management in order to carry out its required functions. Formal communication channels between the various project teams and the EPMO strategic layer are needed to drive the standard data collection process.