ABSTRACT
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) guards the brain by firmly sealing the central nervous system (CNS) from the changeable milieu of blood. Brain delivery represents a great challenge, owing to the presence of the BBB and the BCSFB. Currently, numerous types of drug-delivery methods are developed to combat brain disorders, but most of them have failed due to the existence of these biological barriers. Maintaining typical body functions as well as the transport of therapeutic agents like essential biological elements through biological membranes are extremely vital. In order to get an enhancement of drug CNS performance, copious sophisticated tactics are hastily emerging. Nanoparticulate carriers which are specifically used to deliver drugs to the CNS have obtained great importance due to nanostructure advantages. Similarly, for treating CNS disorders, microtubules-targeting agents are evolving as potential therapeutic targets. Therefore, this chapter represents an outline of barriers to brain drug-delivery and transport mechanisms as well as currently developed brain targeted drug-delivery system and associated challenges.
