ABSTRACT

In spite of the technological advancements, crossing blood brain barrier and achieving sufficient drug concentrations in the brain has been one of the biggest challenges for drug delivery for central nervous systems disorders. Several formulation strategies have been employed to address the issue one such formulation is nanogel, which had displayed promising results in delivering therapeutics to brain. Nanogels are three-dimensional hydrogel particles bearing the sub-micron particle size with the combined advantages of both nanoparticulate system and hydrogels. Properties like biocompatibility, high hydophilicity, high drug loading, stimuli sensitivity, targeting and controlled release make these agents appropriate for drug delivery to brain. This chapter attempts to discuss the various aspects like physiology of brain, nanogels classification, formulation (synthesis), characterization, and finally the application for brain delivery of drugs.