ABSTRACT
All the polyesters, theoretically, can be rendered degradable by the esterification method. However, this is a chemically reversible process and only the aliphatic chains between the ester linkages can degrade within the time required to be useful for biomedical applications. Tissue engineering strategies involve the combination of living cells with a natural/synthetic support or scaffold to develop a biological substitute or a three-dimensional living construct that is structurally, mechanically, and functionally equal to or superior to the tissue to be replaced. The biological affinity used in this context means how a living hard tissue replacement adapts itself to and merges or assimilates with the surrounding living tissue where the replacement is embedded or implanted. Mineralized bone tissue or bone tissue is of two types: cortical and spongy, giving it rigidity and a three-dimensional internal coral structure. Bone serves as a model for making new materials for the replacement of hard tissue.
