ABSTRACT
Endocrine disorders have become a serious issue both in human and in veterinary medicine. According to the literature, excessive obesity affects approximately 45% of the worldwide horse population. Severe obesity of equine metabolic syndrome (EMS) horses is one of the most characteristic clinical features and entails a broad spectrum of physiological consequences, since adipose tissue is shown to be a key player in the development of systemic inflammation. In consequence of this, “inflammaging” in EMS horses seems to be the dominant pathological feature, which suggests a direction for future clinical therapeutic strategies in EMS horses. EMS was also proved to affect different cells and tissues in horse body. It was shown that adipose tissue and liver of EMS horses are characterized by increased mitochondrial damage and mitophagy followed by activation of apoptosis. The impact of algae on the biome of an EMS horse might deliver in future valuable information regarding projection of novel therapies for EMS treatment.
