ABSTRACT
Solanum trilobatum Linn. (Solanaceae) is a probable medicinal plant and is reported to have a wide variety of biological activities for instance antidiabetic, antibacterial, antifungal, antioxidant, antimitotic, arrest blood vomiting, antitumors, antiasthma, and antileprosy. In the present study, we report the antidiabetic effect of ethanol extract of S. trilobatum leaf in alloxan-induced diabetic rats. Graded doses of the ethanol extract were administered to normal and experimental diabetic rats for 21 days. Significant (p < 0.05) reduction in blood glucose levels were observed in the normal as well as in the plant extract-treated diabetic animals. In addition, insulin, liver marker enzymes, catalase, and superoxide dismutase were assessed in the extract-treated diabetic rats and were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine.
