ABSTRACT
The genus Vaccinium (Vacciniaceae) consists of about 450 species, around the world. Berries and leaves of Vaccinium have been an essential source of food and pharmaceutical components and are considered to have high antioxidant potential. The antidiabetic, antihyperlipidemic, and antioxidant action of ethanol extract of V. leschenaultii in streptozotocin (STZ) tempted diabetic rats were examined. Acute toxicity examination of ethanol extract of V. leschenaultii was carried out in rat to decide its dose for the antidiabetic study. Diabetes was provoked in rats by administration of STZ. Ethanol extract of V. leschenaultii at doses of 100, 200, and 400 mg/kg of body weight was managed at a single dose per day to diabetic-induced rats for a phase of 14 days. In acute toxicity, the plant extract did not show toxicity and death up to a dose 1000 mg/kg in rats. The effect of ethanol extract of V. leschenaultii of blood glucose; plasma insulin; creatinine; urea; glycosylated hemoglobin; serum lipid profile: total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and phospholipid; serum protein: albumin and globulin; serum enzymes: serum glutamate pyruvic transaminase, serum 252glutamate oxaloacetate transaminase, and alkaline phosphatase; lipid peroxidation; glutathione reductase; reduced glutathione; superoxide dismutase; and catalase were analyzed in the normal diabetic and drug-treated rats. In the acute toxicity study, ethanol extract of V. leschenaultii was nontoxic at 1000 mg/kg in rats. Ethanol extract of V. leschenaultii possesses significant antidiabetic, antihyperlipidemic, and antioxidant activity in diabetic rats. The decreased blood glucose, increased body weight, glycosylated hemoglobin, and the other biochemical parameter point were examined in diabetic rats and treated with all the quantities of ethanol extract of V. leschenaultii in contrast to diabetic control rats. In diabetic rats, ethanol extract of V. leschenaultii group altered lipid profiles and antioxidant were overturned to near normal than diabetic control rats.
