ABSTRACT
Cancer is now the third leading cause of death worldwide. It is one of the most serious, complex, and diverse life-threatening disease of this century which is spreading further with continuance and increasing incidence. World is endowed with a rich wealth of medicinal plants. So, natural products, called secondary metabolites from plants continue to be an important segment of modern drugs in clinical use as allopathic drugs have many side effects. Extracts and compounds isolated from plants such as Punica granatum, Ixora coccinea, Aegle marmelos, Annona squamosa, Bauhinia variegata, Ruellia tuberosa, Vitis vinifera, Solanum tuberosum, and Ipomoea batatas have been studied for their antiproliferative property in our laboratory. Phytochemicals from these plants have been isolated and in vivo, in vitro, and in silico approaches are employed to investigate their anticancer potential. All the plants showed anti-proliferative property against cancer cell lines and in in vivo model. In silico approach was adopted to determine the drug-like pharmacokinetic profile. All the lead molecules isolated showed acceptable range of Lipinski rule of five indicating their potential for use as drug-like molecules. Further clinical studies are required for their use as drugs for cancer.
