ABSTRACT
Chlorpyrifos (CPF) is a broad-spectrum, chlorinated organophosphate pesticide employed for pest control in various agricultural and animal husbandries. Acute and chronic exposure to CPF can elicit several adverse effects, including oxidative stress. In the present study, we investigated hepatotoxicity and red blood cells (RBC) toxicity of CPF-treated rat and evaluated the antioxidant effect of Commiphora mukul (CM) against oxidative stress in the liver tissues and hematological changes of CPF-treated rat. The rats were divided in different groups; group I—control group (vehicle), group II—30 mg/kg CPF, group III—CM 100 mg/kg with 30 mg/kg CPF, group IV—CM 200 mg/kg with 30 mg/kg CPF, group V—CM 400 mg/kg with 30 mg/kg CPF, and group VI—400 mg/ kg of CM were administered orally via gavages. The results showed that CM overcame the CPF induced and decreased the levels of superoxide dismutase, catalase, glutathione reductase, lactate dehydrogenase, acid phosphatase, Na+/K+-ATPase, and acetyl cholinesterase compared to CPF control. Moreover, CM significantly decreased the lipid peroxidation level 174induced by CPF as compared to CPF control. The drastic alterations in the shape of the RBC were reverted significantly with the increasing doses concentration of CM. These data suggest that oxidative stress as well as RBC toxicity is involved in CPF-induced toxicity and that CM can protect against the tissue damage as well as RBC toxicity induced by CPF.
