ABSTRACT

Nanosuspension is one of the nanotechnology-based drug delivery platforms which has been explored successfully for enhancing solubility and bioavailability of poorly soluble drugs. Nanosuspensions, can thus, be put in the category of nanomedicines. This chapter reviews and discusses multiple aspects of nanosuspension technology, challenges, and applications. Nanosuspensions have emerged as a promising strategy for the efficient delivery of poorly soluble drugs because of versatile features. An outstanding feature of nanosuspensions is the increase in saturation solubility and consequently an increase in the dissolution velocity of the compound. An increased adhesiveness of nanomaterials to surface/cell membranes is usually due to an increased contact area of smaller particles. In nanosuspension technology, the drug has a reduced particle size, which leads to an increased dissolution rate and therefore improved bioavailability. The in vivo performance of nanosuspensions can be improved further by controlling the surface modification of the drug nanoparticles using mucoadhesive polymers.