ABSTRACT

Although schizophrenia is rare (about 1%) of the population, and although people with schizophrenia are more often victims than victimizers, it has been found worldwide that they commit far more crimes than people in general. I emphasize that schizophrenia is a syndrome ranging from mild to severe forms, all with possibly different etiologies. The dopamine hypothesis is the most popular model of causation, but because dopamine antagonists do not work for everyone, other neurotransmitters are a focus of inquiry. The role of epigenetics is also explored as a possible reason why identical twins reared in identical environment are not 100% concordant for schizophrenia. The most modern inclusive theory is the two-hit model whereby genetically susceptible individuals are exposed in utero to inflammatory cytokines (because the mother had contracted an inflammatory disease) that interfere with brain wiring. I also take a brief look at schizotypy.