ABSTRACT
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia, Fax: (499) 137 41 01; E-mail: akrementsova@mail.ru
3.1 Introduction .................................................................................... 30 3.2 Materials and Methods ................................................................... 32 3.3 Results and Discussion .................................................................. 33 3.4 Conclusion ..................................................................................... 37 Keywords ................................................................................................ 39 References ............................................................................................... 39
ABSTRACT
This investigation deals with the actions of aqua Melafen (melamine salt of bis (oximethyl) phosphinic acid) solutions, applied in agriculture, as the plant growth regulator, to the animal tumor cells in vivo. The aqua Melafen
solutions influences to the growth kinetics of experimental malignant neoplasm of mice’s solid tumors carcinoma Luis were tested. We measured the changes of tumor sizes, and the duration of animal’s life in control and experimental groups of mice. The tested doses of Melafen (10-12, 10-9, 10-5 mol/kg) suppressed the growth of carcinoma. Notably, the rate of tumor growth decelerated, and the average tumor volume was decreased at the point of animal death time. The means of lifespan of experimental and control animals were similar. Thereby, we obtained that the Melafen had the appreciable suppressive actions to the tumor development of mice’s Luis carcinoma under the all tested dozes, even under the super low dozes (10-12 mol/kg). The values of the latent periods of the tumor development in the experimental mice’s groups had the same duration, as in control mice groups. The obtained data testify that aqua Melafen solutions slowed the mouse tumor growth, but its does not increase the life expectancy of experimental animals.
