ABSTRACT
The manufacture, transport, and marketing of chemicals and finished products requires the prior toxicological evaluation and assessment of skin corrosivity and skin irritation that might result from intended or accidental skin exposure. Traditionally, animal testing procedures have provided the data needed to assess the more severe forms of skin toxicity, an assessment requiring extrapolation of the data from the animal species to humans [1]. Current regulations may require animal test data before permission is granted for the manufacture, transport, or marketing of chemicals [2], as well as for the formulations that contain them [3].
