ABSTRACT
The appropriate delivery of insulin for achieving euglycemia has been the goal of diabetes therapies in cases of both absolute and relative insulin deficiency. The fact that insulin is the most effective therapeutic choice for lowering blood sugars to normal or near-normal levels was established almost 80 years ago. All people with diabetes mellitus need to achieve the well-known goal of glucose control, set around the world at an HbA1c of 6.5%. The fact that achieving this target results in prevention, stabilization, and reversal of complications associated with diabetes is equally well known as a result of multiple landmark interventional studies. These studies all met the most rigorous of scientific criteria and have set the standards of glucose control to be achieved. The causes of failure to achieve both euglycemia and improvements in the adverse outcomes of patients with diabetes need to be examined, and these factors require rectification.
