ABSTRACT
Chronic renal failure (CRF) is an important cause of secondary dyslipoproteinemia, with abnormalities generally occurring in individuals with renal insufficiency ranging from moderate to severe (1-3). In addition, the superimposed effects of dialysis, nutrition, medications, nephrotic syndrome, and/or the coexistence of an underlying disease may further modulate the lipoprotein profile in this setting. To better understand the abnormalities in lipoprotein metabolism associated with CRF, a brief review of lipids, lipoproteins, and their normal metabolism is discussed. However, for a more comprehensive discussion of lipoprotein metabolism the reader is referred to recent reviews (4-10).
