ABSTRACT

Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin (a 1AT) deficiency, this up-to-date reference discusses the complex pathobiological processes underlying the pathogenesis of a1AT deficiency, describes the a1AT gene and its promoter, and details specific therapies to prevent the major clinical manifestations of the dis

part |2 pages

Part One INTRODUCTION

part |2 pages

Part Two BIOLOGY AND PATHOBIOLOGY

chapter 2|12 pages

Alpha 1-Antitrypsin Gene and Promoter

chapter 3|12 pages

Alpha 1-Antitrypsin Gene Evolution

chapter |13 pages

ABC

chapter 6|20 pages

The Three-Dimensional Structure of alA T

chapter 12|12 pages

Transgenic Animals with the alAT Promoter

part |2 pages

Part Thr ee CLINICAL MANIFESTATIONS

chapter 14|16 pages

Laboratory Diagnosis of alA T Deficiency

chapter 15|18 pages

Clinical Manifestations of alA T Deficiency

chapter 16|14 pages

Lung Function and alA T Deficiency

chapter |1 pages

270Fallat

chapter |10 pages

alATDeficiencyandRAWD271

chapter 18|12 pages

Natural History of alA T Deficiency

part |2 pages

Part Fou r TREATMENT

chapter 21|14 pages

Therapy of alA T Deficiency

chapter 22|8 pages

Augmentation of Liver Production

chapter 24|16 pages

alA T Deficiency and Liver Transplantation