ABSTRACT
I. Primary Immunodeficiency 343
II. Secondary Immunodeficiency Syndromes 344
References 346
I. Primary Immunodeficiency
Despite technological advances in prenatal and early postnatal diagnosis for
genetically inherited immunodeficient diseases, most primary or congenital
immunodeficiencies continue to be clinically detected because of recurrent, or
unusually chronic infections. Among these, rhinosinusitis, which has been recog-
nized as a source of infection in healthy children, plays a major role. Children
with cystic fibrosis, ciliary dyskinesia syndrome (which includes Kartagener’s
syndrome), and immunoglobulin deficiencies frequently present with radio-
graphic evidence of chronic sinus disease (1,2).
