ABSTRACT

It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics:

  • Early research on radioprotectors
  • WR-2721, an aminothiol prodrug, as a radioprotector
  • New results with naturally occurring thiols
  • Nitroxides as effective radioprotectors in vitro and in vivo
  • Radioprotection observed with radical scavengers or antioxidants
  • Bone marrow radioprotection with cytokines and biological modifiers
  • Multiple mechanisms of altering radiation response by eicosanoids
  • Vascular response to radiation and the importance of vascular damage to normal tissue
  • Modifiers of radiation-induced apoptosis
  • Survey of clinical trials with radioprotectors
    Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
  • section Section I|183 pages

    Chemical Aspects of Radioprotection

    chapter |11 pages

    Introduction

    chapter Chapter 1|10 pages

    History of Radioprotector Development

    chapter Chapter 3|55 pages

    Aminothiols

    chapter Chapter 5|24 pages

    Radioprotection by Superoxide Dismutase

    section Section II|129 pages

    Biochemical and Biological Perspectives

    chapter Chapter 10|16 pages

    Modulation of the Radiation Response by Cytokines

    section Section III|95 pages

    Radioprotection of Normal Tissues