ABSTRACT

Tachykinins-namely, substance P (SP), neurokinin A (NKA), and neuro-

kinin B (NKB)—are members of a family of neuropeptides that are widely distributed in sensory nerves and in the central nervous system (CNS).

They play a pivotal role in airway neurogenic inflammation, bronchocon-

striction, immunomodulation, and cough.