ABSTRACT

I. Introduction 594

II. Screening of Transplant Candidates 594

III. Complications in the Transplant Recipient 597

A. Reperfusion Pulmonary Edema/Primary Graft Failure 597 Radiographic Considerations 597

B. Airway Complications 598

Radiographic Considerations 599

C. Native Lung Hyperinflation 600

Radiographic Considerations 602

D. Infectious Complications 602

Radiographic Considerations 604

E. Post-transplant Lymphoproliferative Disease 606

Radiographic Considerations 607

F. Lung Cancer 607

Radiographic Considerations 608

G. Acute Allograft Rejection 609

Radiographic Considerations 609

H. Bronchiolitis Obliterans Syndrome 611

Radiographic Considerations 612

Acknowledgment 615

References 615

I. Introduction

Human lung transplantation was first attempted in 1963 but it was not until

two decades later that extended survival was achieved. Further refinements in

patient selection, surgical technique, immunosuppression, and post-operative

care have led to the successful application of lung transplantation to a wide

variety of advanced disorders of the airways, lung parenchyma, and pulmonary

vasculature (1). There has been a marked proliferation of lung transplant

centers worldwide and by the end of 2001, 14,000 procedures had been performed (2).