ABSTRACT
Granulation of powders is a well-known process in the pharmaceutical industry where primary particles are made to adhere in order to form larger entities called granules. Primarily, it is used for an improvement of the flow characteristics as well as for assuring the homogeneity and mechanical stability of the blend during further production steps. Especially for the compaction of modern actives, granulation is often unavoidable due to the hydrophobic characteristics of these substances. By binder granulation the actives are ‘‘coated’’ with a hydrophilic agent, thus establishing electrostatic interactions between the granulate particles and enabling water to penetrate the tablet in order to improve disintegration and dissolution behavior.
