ABSTRACT

Binders are adhesives that are added to solid dosage formulations. The primary role of binders is to provide the cohesiveness essential for the bonding of the solid particles under compaction to form a tablet. In a wet-granulation process, binders promote size enlargement to produce granules and thus improve flowability of the blend during the manufacturing process. Binders may also improve the hardness of the tablets by enhancing intragranular as well as intergranular forces. In a direct compression process, binders often act as fillers and impart compressibility to the powder blend. The cohesive properties of binders may reduce friability of the tablets and thus aid in their durability and elegance. Although the purpose of using binders in a tablet formulation is not to influence its disintegration and dissolution rate, these properties may be modified due to the altered wettability of the formulation.