ABSTRACT

Therefore, in normal subjects, postural reduction in

blood pressure is usually 20/10 mmHg and increase in heart rate is 30 beats/min. Any abnormalities in the arterial or cardiopulmonary baroreceptors, afferent nerves, the

nucleus tractus solitarius where the afferent nerves termi-

nate, and the efferent nerve output in the sympathetic

nervous system to increase norepinephrine release to the

heart and blood vessels can lead to OH. On the other

hand, patients with severe reduction in intravascular

volume may experience OH or tachycardia despite intact

autonomic nervous system function.