ABSTRACT
Total joint replacements are generally highly successful operations with acceptable longevity. Whether the prosthesis is cemented or cementless, if the materials selected are biocompatible, and based on the component design and surgical technique are optimized, hip and knee arthroplasties have a survivorship of 15 years with over a 90% probability. The key to the success of joint replacement is the host’s biological response to the implant. In this chapter, we will explore the histopathology of total joint replacements including the tissue response to well-functioning orthopaedic joint prostheses, and those undergoing failure due to loosening and osteolysis.
