ABSTRACT
I. Introduction 399
II. In Vitro Studies 400
A. Influence of Surfactant on Bacterial Growth 400
B. Influence of Surfactant on Leucocyte Function 405
III. Animal Studies 407
IV. Clinical Studies 409
V. Summary and Perspectives 414
VI. Conclusion 416
Acknowledgments 417
References 417
I. Introduction
During the last decade, surfactant administration has become standard for treat-
ment of premature neonates with severe respiratory distress syndrome (RDS).
Randomized controlled trials and meta-analyses clearly demonstrate improved
gas exchange following surfactant instillation as well as significantly reduced
neonatal morbidity and mortality (1).