ABSTRACT

For some time it has been recognized that lipophilic compounds can present a problem in the in vitro measurement of percutaneous absorption. Compounds that are insoluble in water may not partition freely from excised skin into an aqueous receptor fluid. The problem was alluded to by Franz (1), who in selecting compounds for the study, omitted highly water-insoluble compounds to avoid results that were ‘‘artificially limited due to insolubility in the dermal bathing solution.’’