ABSTRACT
It is now very well known that the majority of organic compounds are capable of being crystallized into more than one structural form (1-11). Polymorphism is defined as the situation where the different crystal forms of a compound are found to be identical in their elemental composition, while solvatomorphism is defined as the situation where the various crystal forms of a compound differ in their solvation or hydration state. The development of a full understanding of the stability relationships between polymorphs and solvatomorphs is vitally important to a preformulation program, as the selection of the proper form is crucial even at the earliest stages of development.
