ABSTRACT

The effects of solvents and vehicles on the skin are important since skin is the largest

organ of the human body and provides protection against the external environment.

In addition, the skin enables us to maintain a state of homeostasis. However, skin

and its barrier properties may be altered when exposed to various chemical agents.

Exposure to solvents and vehicles can occur after occupational or accidental

spillage, topical application of cosmetics, sunscreens, insect repellents, as well as

following the topical application of drugs for therapeutic purposes.