ABSTRACT
Inflammation is an old concept, originally recognized as a contributor to disease by the Romans. During that time inflammation was defined as ‘‘rubor, dolor, tumor, calor, functiolasae,’’ or redness, pain, swelling, heat, and loss of function. Subsequent to these early observations, it was not until the 1800s that cellular processes were observed to contribute to inflammation, typically seen in microscopic analyses of human and experimental conditions. In the last 40 years, studies
began to dissect the mechanisms of inflammation including identification of protein regulators of that control the cellular responses.
