ABSTRACT

Mundulea sericea (Willd.) A. Chev. is a small tree belonging to the family Fabaceae, and various parts like bark, leaves, seeds, and roots of this plant are used for various medicinal purposes. This plant has been used as fish poison, insecticide, aphrodisiac, anti-microbial, analgesic, and anti-oxidant activities. Hence, the present study aims to analyze the anti-diabetic and cytotoxicity activities of the ethanol bark extract of Mundulea sericea. In vitro anti-diabetic activity by using α-amylase, α-glucosidase, and in vitro cytotoxicity assays through various cell lines viz. vero, cervical (HeLa), lung (A-549), liver (Hep-G2), and breast (MCF-7) carcinoma was evaluated using the MTT assay. Results showed that the extract exhibited significant activity of α-amylase, as well as α-glucosidase inhibitory activities, which inhibition was 59.22 and 65.27, respectively, at 500 µg/mL concentration. The standard acarbose inhibition value was 81.97. The extracts also have significant cytotoxicity in the HeLa cancer cell compared to other cytotoxicity cells and which the IC50 value was 76.11 μg/mL. Thus, the plant bark of Mundulea sericea could potentially be a rich source of natural anti-diabetic and anti-cancer medicine.