ABSTRACT
The change in lifestyle and food habits of humans led to metabolic disorders like Diabetes mellitus. It is time for searching plant-based drugs. The aim of the present study was to evaluate the anti-diabetic activity of ethanolic extracts of in vivo and in vitro shoots of Cleome gynandra in alloxan-induced diabetic Wistar albino rats. A total of 25 rats were equally divided into five groups as normal control, diabetic control, glibenclamide-treated (5 mg/kg), in vivo, and in vitro sample-treated (150 mg/kg). Blood glucose levels were measured on the 4th, 7th, 14th, and 21st days by a OneTouch Glucometer. The ethanolic extracts (150 mg/kg) of the in vivo, in vitro shoots showed better reduction in blood sugar levels of 124.21 ± 5.21 mg/dL and 121.32 ± 4.41 mg/dL, respectively, on the 21st day. These blood sugar levels were very close to the blood sugar levels of the normal control and glibenclamide-treated animals. The in vivo and in vitro samples of C. gynandra reduced the blood sugar levels significantly (P < 0.01 & P < 0.001) in tested animals.
