ABSTRACT
This chapter begins with an overview of diverse synthesis and characterization methods of magnetic nanoparticles (MNPs), with emphasis on precisely controlled and eco-friendly ways. It highlights the role of surface modification in offering biostability and conjugating/targeting functionalities. The chapter examines potential toxic effects that may hinder the future clinical translation of MNPs. Bare nanoparticles always tend to aggregate to reduce the total surface energy, and depending on their composition, they can be prone to oxidation, especially in humid environment. Colloidal stability of MNPs is prerequisite for feasible medical applications in biological environments. Stabilization of nanoparticle surface can be achieved by employing organic monomers with functional groups like carboxylate, phosphate, phosphonates, and sulfate. Targeted modification of MNPs has been tried for other diseases, such as Alzheimer’s disease and arthritis.
