ABSTRACT
This chapter deals with the selected drug delivery applications, their biofate and formulation consideration. It focuses on the therapeutic applications and formulation constituents of nanoemulsions for ocular, injectable, oral and topical application with the overview on the influence of materials on their biofate. Nanoemulsions are heterogeneous systems in which one immiscible liquid is dispersed as droplets into another liquid. Several strategies in the formulation of nanoemulsions for ocular therapeutics were found to be effective in increasing bioavailability. Cationic nanoemulsion is one of the approach which benefits from the electrostatic interaction between negatively charged bio-membrane to transport the drug-bearing nanoemulsion across it, thereby increasing bioavailability and reducing plasma clearance. The oral route of drug delivery is the most preferred and patient convenient route of drug administration. Emulsifiers are amphiphilic molecules which stabilize nanoemulsions by reducing interfacial tension, thereby preventing aggregation of droplets.
