ABSTRACT
A limitation of CoSyn, presented in Chapter 5, is that it assumes direct-addressing of valves using pressure ports; this design approach is prohibitively expensive especially with large reconfigurable fabrics. In this chapter, we address this limitation by presenting a pin-constrained design methodology for high-throughput single-cell screening using reconfigurable flow-based microfluidics. For performance assessment, the proposed design is analyzed using computational fluid dynamics simulations, mapped to an RC-distributed model, and combined with inter-valve connectivity information to construct a high-level synthesis framework, referred to as Sortex. Simulation results show that Sortex significantly reduces the number of control pins and fulfills the timing requirements of single-cell screening. This chapter concludes the second part of the book on design support for single-cell analysis.
