ABSTRACT
In this chapter, the authors return to the subject of nervous system wiring, a problem of central importance in neurobiology. They discuss visual system wiring to the rest of the nervous system and expand on the principles governing neural developmental processes. The reason Slit and Robo mutants do not exhibit identical phenotypes is because additional Robo proteins act together with Robo, as discussed in the following. A phenomenon related to dendritic self-avoidance is dendritic tiling, introduced in the context of retinal neuronal types. They discuss how sites for synapse formation are selected, and subsequent sections address how synaptogenesis occurs and had followed the developmental sequence of individual neurons, from patterning of progenitors and regulation of neurogenesis to establishment and refinement of synaptic connections.
