ABSTRACT
This chapter focuses on the development of Polycaprolactone (PCL)-based antimicrobial nanocomposite fibers, where it explores the fabrication and designing of nanofillers encapsulated in antimicrobial PCL nanofibers. PCL demonstrates rheological and viscoelastic properties, which enable ease of fabrication with different manufacturing techniques, exploited for scaffold designing in various biomedical applications. The addition of nanofillers of a different nature to PCL electrospun fibers enhance the physical properties of the fibers by altering their mechanical thermal properties or biodegradation behavior and also introduces an antimicrobial quality. The antimicrobial nature of the nanocomposite was investigated against Staphylococcus aureus and Escherichia coli by the zone of inhibition method. The antimicrobial activity of the amoxicillin (AMX)-loaded membranes depends on both AMX and nanohydroxyapatite contents. An attempt has been made to compile the studies where nanofillers play multiple roles that develop the inherent antimicrobial nature in the nanofibers.
