ABSTRACT
Inoue et al. analyzed the sleep-modulatory effects of Delta-Sleep-Inducing Peptide (DSIP) by their long-term i.c.v. infusion technique (into the third cerebral ventricle). The earliest samples of DSIP exhibited a marked, prompt, but short-lasting slow-wave sleep-inducing activity at a dose of 2.5 nmol/10 h per animal during a nocturnal period. Krueger et al. reported that DSIP (18 nmol) was ineffective when i.c.v. infused for 90 min in rabbits. Tobler and Borbely demonstrated that in rats neither an acute injection of DSIP into the lateral cerebral ventricle (8 nmol per animal) or the third cerebral ventricle (24 nmol), nor a 1.5-to 2-h infusion into the third cerebral ventricle (7 nmol) resulted in a change in the amount of total sleep. Improvement of sleep to normal values occurred by the end of the DSIP administration and was maintained during a subsequent 1-week follow-up period. In nine similarly treated elderly insomniacs (60 to 83 years) the immediate effect was larger.
