ABSTRACT
Piperidine is a biogenic amine and a normal constituent of the central nervous system of both invertebrates and vertebrates, and regarded as a neuromodulator or a hypnogenic substance. According to the American researchers, the effects of Growth hormone-releasing factor (CRF) may be ascribed to an action of reducing the activity or release of hypothalamic CRF or a production of an indirect effect on other sleep modulators. Luteinizing hormone-releasing hormone (LHRH) is a hypothalamic decapeptide, which stimulates hypophyseal gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone. Although sleep-related LH secretion is well known to occur around puberty in humans, LHRH seems to have no sleep-modulatory activity. Riou et al. reported that no sleep-modulatory effect was observed after i.c.v. injection of ß-endorphin (1 µg) in rats during the light period. Recently, Alho et al. demonstrated that a neuropeptide termed diazepam-binding inhibitor was identified in the rat brain.
