ABSTRACT
The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.
All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.
Volume I 1. Ion Selectivity and Conductance 2. Voltage-Dependent Gating of Ion Channels 3. Ligand-Dependent Gating Mechanism 4. Mechanosensitive Channels and Their Emerging Gating Mechanisms 5. Inactivation and Desensitization 6. Ion Channel Inhibitors 7. Expression of Channels in Heterologous Systems and Voltage Clamp Recordings of Macroscopic Currents 8. Patch Clamping and Single-Channel Analysis 9. Patch Clamp Recordings from Native Cells and Isolation of Membrane Currents 10. Models of Ion Channel Gating 11. Investigating Ion Channel Structure and Dynamics Using Fluorescence Spectroscopy 12. Ion Channel Structural Biology in the Era of Single Particle Cryo-EM 13. Protein Crystallography 14. Rosetta Structural Modeling 15. Molecular Dynamics 16. Genetic Models and Transgenics 17. EPR and DEER Spectroscopy Volume II 1. Taxonomy and Evolution of Ion Channels 2. Voltage-Gated Sodium Channels 3. Voltage-Gated Calcium Channels 4. Voltage-Gated Potassium Channels 5. ERG Family of K Channels 6. KCNQ Channels 7. BK Channels 8. Small-Conductance Calcium-Activated Potassium (SK) Channels 9. Inward Rectifier Potassium Channels 10. Two-Pore Domain Potassium Channels 11. Cyclic Nucleotide-Gated Channels 12. HCN Channels 13. CLC Chloride Channels and Transporters 14. Ca-Activated Cl- Channels 15: Acetylcholine Receptors 16. Ionotropic Glutamate Receptors 17. 5-HT3 Receptors 18. GABAA Receptors 19. Glycine Receptors 20. Acid Sensing Ion Channels 21: ENaC Channels 22. TRPC Channels 23. TRPM Channels 24. TRPV Channels 25. Store-Operated CRAC Channels 26. Piezo Channels 27. Ryanodine Receptors 28. Proton Channels 29. P2X Receptors Volume III 1. Alternative Splicing 2. Calmodulin Regulation of Ion Channels 3. Mechanism of G-protein Regulation of Ion Channels 4. Regulation of Ion Channels by Membrane Lipids 5. Ion Channels of the Heart 6. Ion Channels in Sperm and Eggs 7. Ion Channels in Immune Cells 8. Ion Channels in Epilepsy 9. Ion Channels in Pain 10. Cystic Fibrosis and the CFTR Anion Channels 11. CLC-Related Proteins in Diseases 12. KATP Channels and the Regulation of Insulin Secretion
