ABSTRACT
Introduction Chinese herbal medicine originated in China 3000 years ago on the basis of clinical experience and practice, and was introduced in Japan in the fifth century. There are many prescriptions that have been handed down since then, but the effective ingredients have usually not been identified. Sho-saiko-to (Xiao-Chai-Hu-tang in Chinese) is one of the most popular prescriptions and has been widely used in Japan.
