ABSTRACT
The association between obesity, cardiovascular risk factors, and cardiovascular disease is well established.1 Compared to normal-weight subjects, obese individuals (BMI ≥30 kg/m2) have an about 3.5-fold increased risk for type 2 diabetes and hypertension, a 2fold increased risk for hypercholesterolemia, and a 50% increased risk for cardiovascular disease.2,3 Consequently, numerous studies have investigated weight reduction interventions for people with obesity, and epidemiologic studies have estimated the potential benefits that may be expected from preventive measures.1
