ABSTRACT
The fact that all neurotoxic agents do not necessarily produce the same neurotoxic profile must be based largely in differing modes or mechanisms of action. It follows that one key to developing a better understanding of the mechanism(s) of a neurotoxicant is to first define its neurotoxic profile. By examining the selective damage produced by an agent over a range of doses, an understanding of that agent’s mechanism can be achieved. The siteselective action of an agent can be defined at the molecular, cellular or tissue level of an organism. The following examples of site-selective neurotoxicity are provided to indicate how site selectivity can be related to mode or mechanism of action.
