ABSTRACT
It has been suggested that a deficiency in ALDH2 isozyme may provide protection against alcoholism. In this paper, the genotypes of ALDH2 locus were determined in healthy Japanese and the acetaldehyde metabolism after alcohol intake was investigated using a gas chromatography technique. The gene frequencies of ALDH https://www.w3.org/1998/Math/MathML"> 1 2 https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9780203776766/69ece17c-e0ab-4d29-b51f-c55a8c5703b4/content/inline1_B.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/> and ALDH https://www.w3.org/1998/Math/MathML"> 2 2 https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9780203776766/69ece17c-e0ab-4d29-b51f-c55a8c5703b4/content/inline2_B.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/> were compared between healthy controls and alcoholic patients. The individuals possessing the homogenous genotypes of ALDH https://www.w3.org/1998/Math/MathML"> 2 2 https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9780203776766/69ece17c-e0ab-4d29-b51f-c55a8c5703b4/content/inline3_B.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/> showed strong sensitivity to alcohol due to a higher formation of blood acetaldehyde after alcohol intake.
