ABSTRACT
In contrast, the later part of the curve (Figure 32.1) falls because of metabolism and elimination. This carries much more interpatient variability, the serum concentration at a given time sometimes varying by a factor of 10 from one person to another. This has two important consequences:
? Although predictable for populations, elimination kinetics, half-lives, and clearance (see Chapter 19) are difficult to predict for individuals. It is difficult to know when the agent will be completely cleared from the body.
