ABSTRACT
The ultimate goal for the HIV-infected person would be the eradication of HIV infection. However, this is unlikely to be achieved as the virus integrates into the host chromosome, and therefore all infected cells would have to be removed. This may be possible in renewable tissue, such as lymphoid cells, but not within the nervous system, where cells cannot be replaced. However, if the virus could be suppressed to the level where it is not damaging the host or continuing to infect new cells, then the disease process may be halted. The virus can potentially be inhibited in three ways: (1) by preventing binding or fusion to the target cell; (2) by inhibiting replication and release; and (3) by inducing noninfective particles (Figure5.1).
