ABSTRACT
Information from a number of cross-sectional
studies suggests that PAI-1 is positively
correlated with BMI.14-18 Swedish
investigators measured PAI-1 activity in 260
volunteers, aged between 30 and 60 years and
found a correlation between PAI-1 and BMI
in both men and women.14 In the North
Sweden MONICA study of 1,558 men and
women aged between 25 and 64 years,
haemostatic factors including PAI-1 activity
were measured and found to be correlated
with anthropometric measures, as well as
various other metabolic indices and blood
pressure.15 This study demonstrated a strong
correlation between PAI-1 and BMI. An
association between PAI-1 and adiposity has
also been demonstrated in children aged
between 7 and 11 years.18 It would seem that
even in early childhood, obesity is associated
with unfavourable changes in haemostatic
factors. Landin et al reported increased PAI-1
concentrations in obese subjects when
compared to a control group of lean women.19
The investigators went on to show that PAI-1
concentrations were significantly higher in 10
