ABSTRACT
Several large epidemiological studies have
demonstrated that fibrinogen is correlated
with both BMI and WHR.59-65 Some
investigators have seen this association in both
men and women,63 while others have found
statistically significant results in women
only.60,64
In the Scottish Heart Health Study
multivariate analysis showed that fibrinogen
was positively associated with BMI, although
the association was weaker in men compared
to women.63 In the third Glasgow MONICA
survey, 746 men and 816 women were
randomly sampled to establish associations
between certain haemostatic factors and risk
factors for cardiovascular disease.64 In this
study fibrinogen was correlated with BMI in
women but not in men. Likewise in the
Framingham study fibrinogen concentrations
increased with measures of adiposity in
women but not in men.60 Krobot et al
examined the relationship between fibrinogen
levels and various other cardiovascular risk
factors in 4,434 subjects.62 Fibrinogen was
positively correlated with BMI and WHR in
men and women. In men the relationship
between fibrinogen and WHR was stronger
than the relationship between fibrinogen and
BMI. The opposite was true for women. In
the PRIME Study, fibrinogen and a number
of other haemostatic variables were measured
in 10,500 men.61 Fibrinogen was more
strongly correlated with WHR than BMI.
