ABSTRACT
Given the availability of two drugs with different
modes of action, it is inevitable that they will be
tried in combination, as is commonly the case
with drugs for hypertension and diabetes. One
small placebo-controlled study suggested that
there was no additional benefit to adding orlistat
after 1 year of sibutramine treatment,32 but a
formal study combining the two treatments has
not been carried out. At present this
combination is contraindicated in the license of
both drugs, and is not recommended by any of
the published guidelines on obesity treatment
Perhaps of more clinical relevance will be a
carefully controlled study of the sequential use of
sibutramine and orlistat.
