ABSTRACT
In this overview we will focus on the management of H. pylori-associated PUD, because the majority of gastroduodenal ulcers in the absence of salicylate or NSAIDs, are related to H. pylori. NSAIDs are also a major cause of ulceration. Patients on long-term NSAID treatment have gastric erosions in 20-40%, gastric ulcers in 10-25% and/or duodenal ulcers in 2-5%. However, it is being increasingly recognized that ulcers can occur apparently in the absence of H. pylori infection or the use of NSAIDs; these are so-called idiopathic ulcers.
