ABSTRACT
In the 60 years since Charles Huggins established the scientific basis for the treatment of advanced prostate cancer by androgen ablative therapy, the urological community has concentrated on refining the means of restraining the influence of testosterone on the gland. Androgens were seen as the predominant growth promoter. During this time, it was recognized that prostate cancer is a disease of the middle-aged man, involving a slowly growing tumor that takes 25 or more years to develop from a focal lesion to the malignant aggressive phenotype. But recent years have witnessed a revolution in medical science, with men now presenting with early cancer, small enough to be removable by surgery or treated with radiotherapy. The urologist can now cure prostate cancer.
